A feasibility study of promoting osseointegration surface roughness by micro-milling of Ti-6Al-4V biomedical alloy

Abstract The reliability of a prosthetic implant needs durability, biocompatibility, and osseointegration capability. Accomplishing these characteristics, Ti-6Al-4V alloy is the main used material for fabrication. Moreover, it can be processed by additive manufacturing technique, permitting to meet patience-tailored, often complex shaped, prosthesis topologies. Once an realized, finished machining operations its capability heavily influenced resulting surface roughness. Consequently, assessment this latter mandatory evaluate durability. This paper presents analysis roughness micro-milled specimens produced plastic deformation, selective laser melting, electron beam melting processes. A central composite design was employed planning cutting tests. comparison between results values enhancing osseointegration, firstly permitted individuate range micro-milling suitable applications, which have been individuated as ball joints, bone plates, screws. Next, statistical experimental measurements allowed identification most influential parameters together with determination mathematical models response methodology. good among calculated revealed model, allowing prediction achievable once micro-machining are selected, or their optimization function desired value.